2nd World Heart Congress
Mustafa Kemal University, Turkey
Title: Cut-off values of ischemia modified albumin for the exclusion of aortic aneurysm
Biography: Oguz Akkuş
Aim: Due to disturbing symptoms and catastrophic outcomes, aneurysms require more attention and closer follow-up. We aimed to evaluate whether ischemia modified albumin (IMA) values are increase in patients with aortic aneurysm and predictive to differentiate those patients.
Methods: Our study population consisted of patients with aortic aneurysm (n=57) and age-matched control subjects (control group) (n=58).
Results: The high sensitive C reactive protein (hsCRP), IMA, low-density lipoprotein (LDL) and total cholesterol levels were significantly higher in aneurysm group than the control group (p<0.05 for all). High-density lipoprotein (HDL) cholesterol level was significantly lower in the aneurysm group (p<0.05). LDL, total cholesterol, hsCRP and IMA levels were significantly correlated with maximum aortic diameter (r=0.210, p=0.024, r=0.469, p<0.001, r=0.472, p<0.001 and r=0.698, p<0.001, respectively). The cut-off value of IMA obtained by ROC curve analysis was 0.48 for prediction of aortic aneurysm (sensitivity: 100.0%, specificity: 100.0%).
Conclusion: Low IMA levels may be a useful marker in excluding an aortic aneurysm with a high sensitivity and specificity, preferably when aneurysm considered as low probability and in patients without any ischemic event ever.