World Heart Congress
Tongji University School of Medicine, China
Title: Development of nano carriers for medical diagnosis and treatment
Biography: Donglu Shi
In this presentation, we report the design of a new nanostructure that ideally satisfies the important biomedical requirements in medical diagnosis and treatment. Quantum dots (QDs) were conjugated on magnetic nano spheres (MNS) of polystyrene-Fe3O4 composites. Surface-associated QDs on these MNS exhibited intense visible emissions using fluorescent spectroscopy and successfully facilitated in vivo soft tissue imaging in mice. Furthermore, application of an alternating electromagnetic field effectively induced heating of the MNS into temperature ranges suitable for therapeutic hyperthermia. The magnetic nano spheres were incorporated with PLGA for drug delivery through an emulsion technique. The drug loading efficiency of PLGA-coated MNS were investigated. MNS were also functionalized with antibodies to target a lesion. Experimental results on MNS surface structure development, in vivo imaging, cell targeting, and hyperthermia will be presented. Future requirements, aims, and trends in the development of multi-functional nano particles, including graphene, particularly with intelligent functionalities for fundamental studies, are also given in this presentation.